Cognitive resilience was defined as the modification of total cerebral volume’s association with cognition, such that smaller β estimates (presented in SD units) indicate greater cognitive resilience (ie, better cognitive performance than estimated by lower total cerebral volume). Main Outcomes and Measures The primary outcome was a global measure of cognitive function. Data were analyzed from May 22, 2017, to June 1, 2021.Įxposures Total cerebral volume and, as a modifying exposure variable, self-reported availability of 5 types of social support measured by the Berkman-Syme Social Network Index. Data from this large, population-based, longitudinal cohort were collected from June 6, 1997, to Decem(original cohort), and from September 11, 1998, to Octo(offspring cohort). Objective To examine the association of individual forms of social support with a global neuroanatomical measure of early ADRD vulnerability and cognition.ĭesign, Setting, and Participants This retrospective cross-sectional analysis used prospectively collected data from Framingham Study participants without dementia, stroke, or other neurological conditions who underwent brain magnetic resonance imaging and neuropsychological testing at the same visit. Studies suggest that supportive social networks reduce Alzheimer disease and related disorder (ADRD) risk by enhancing cognitive resilience, but data on specific social support mechanisms are sparse.
Importance Cognitive resilience refers to the general capacity of cognitive processes to be less susceptible to differences in brain structure from age- and disease-related changes. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.
Clinical Implications of Basic Neuroscience.
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